Clio grew up in Brussels with Greek-Dutch nationality. She studied piano and flute with Carmen-Elena Rotaru and Denis-Pierre Gustin and earned her Licentiate Diploma in Piano with distinction from Trinity College London, receiving several prizes.

Clio studied law at Utrecht, Cambridge, Oxford, and the College of Europe. While working as a lawyer, she joined a conducting workshop for legal professionals led by the Concertgebouw Orchestra and Antony Hermus. She later trained with Achim Holub in Valencia and London and completed an advanced course at Juilliard Extension under Mark Shapiro. Since 2024, she has studied conducting with Roland Melia.

She first joined the BCS as a soprano in 2016 and became Assistant Musical Director in 2019. She is also co-founder and principal conductor of the Brussels Chamber Ensemble and has conducted other Brussels-based ensembles like BachWerk and the Association Philharmonique d’Uccle.

Clio has been Acting Musical Director of the BCS since June 2025.